Myhep All (Sofosbuvir and Velpatasvir)

Myhep All is a fixed-dose combination drug of sofosbuvir , a nucleotide analog that inhibits HCV NS5B polymerase, and velpatasvir, a new NS5A inhibitor. The drug stops the reproduction of the virus in the blood. Each tablet contains 100 mg of Velpatasvir and 400 mg of Sofosbuvir. Together, these two substances work as a potent anti-HCV agent.

Indications for use

The drug is intended for the treatment of chronic hepatitis C genotypes 1, 2, 3, 4, 5 and 6 in patients older than 18 years without cirrhosis or with compensated cirrhosis;

With decompensated liver cirrhosis with the combined use of ribavirin.

Mode of application

• In patients without cirrhosis of the liver or with compensated cirrhosis ( cirrhosis of the liver of class A ), a course of 12 weeks is prescribed.
• Combination therapy is recommended for patients with decompensated cirrhosis of the liver ( cirrhosis of the liver of class B and C ) *: 12-week course of Velpatasvir in combination with Ribavirin.
• In combination therapy, the recommended dose of ribavirin is calculated based on body weight (taken with food): 1000 mg per day for patients whose body weight is not more than 75 kg, and 1200 mg for patients whose body weight is more than 75 kg, divided by 2 reception. The dose at the beginning of treatment, as well as during treatment, can be reduced based on the indications of hemoglobin and creatinine clearance. To change the dose of ribavirin, you must read the instructions for use of the drug.
• The course of treatment should be set by the doctor. He sets the dose, carries out its adjustment, if at the same time other drugs are taken that interfere with the action of the drug Velpatasvir.
• If during the course of therapy using Velpatasvir side effects of severity 1 and 2 appear , you should continue taking the drug as usual. With complications of a high severity or treatment failure, the course must be interrupted.
• The medicine is best taken with meals, washed down with copious amounts of water. Take the drug daily at the same time.

Contraindications

Do not take the drug and inform your doctor immediately if: you are allergic to sofosbuvir, velpatasvir, or any other component of the drug. The combined treatment regimen using velpatasvir, sofosbuvir and ribavirin is contraindicated in patients with contraindications to ribavirin.

• Precautionary measures
• Before starting the reception, inform your doctor about any existing diseases :
• liver diseases, in addition to hepatitis C;
• severe kidney disease or the use of hemodialysis;
• severe symptomatic bradycardia, in which sofosbuvir is prescribed together with amiodarone and another direct-acting antiviral drug for the treatment of hepatitis C;
• pregnancy or pregnancy planning (the effect of the drug on the fetus has not been studied);
• women taking the drug together with ribavirin are not recommended to become pregnant during the course of treatment and 6 months after the end of treatment. If pregnancy was detected during combination therapy with sofosbuvir, vepatasvir and ribavirin, you should immediately consult a doctor;
• breastfeeding or its planning (the penetration of the components of the drug into breast milk has not been studied).

Use in children

The drug is not recommended for children and adolescents under the age of 18 years , since there are no data on the safety and effectiveness of the drug.

Overdose

If the dosage is exceeded, the patient should be examined for signs of intoxication. Treatment in case of overdose consists in general supportive measures, including monitoring of vital functions, as well as monitoring the patient's clinical condition.

Interaction with other drugs

You should tell your doctor about all prescription and OTC drugs , vitamins, or dietary supplements you are taking. This drug may interact with certain medicines. Always warn your doctor about starting or stopping the use of certain drugs. Do not take other drugs containing sofosbuvir (one of the active components of the drug).You can get sofosbuvir velpatasvir cost in Indian pharmacy 100% Lowest price.

P-glycoprotein inducers and / or moderate and strong inducers of CYP2B6, CYP2C8 and CYP3A 4 (e.g. rifampicin, St. John's wort, carbamazepine) can lower the concentration of sofosbuvir and velpatasvir in the blood, which can lead to a decrease in the therapeutic effect. The use of these drugs with sofosbuvir and vepatasvir is not recommended.

Talk to your doctor or pharmacist if you are taking medications to treat stomach ulcers, heartburn, or acid reflux :

• Antacid (magnesium / aluminum hydroxide);
• proton pump inhibitors (omeprazole);
• H2 - histamine receptor blockers (famotidine)
• Tell your doctor or pharmacist if you are taking one of the following drugs:
• Amiodarone for the treatment of arrhythmias;
• tenofovir disoproxil fumarate or any drug containing it used to treat HIV;
• digoxin for the treatment of heart disease;
• HMG-CoA reductase inhibitors (rosuvastatin, atorvastatin).

Release form

Oval-shaped tablets coated with a film shell engraved in the form of a six-pointed star on one side and dividing lines on the other. Packed in a plastic jar with a screw cap containing a mechanism for controlling the first opening, with the neck protected by a sealing membrane. The jar contains 28 tablets .

Storage conditions

Keep out of the reach of children.

Store at a temperature below 30 ° C . Do not take the drug after the expiration date.

Store in the original packaging for protection against moisture.

Composition

Active ingredients : The active ingredients of Myhep All are sofosbuvir and velpatasvir. Each tablet contains 400 mg of sofosbuvir and 100 mg of velpatasvir. Inactive components : copovidone, croscarmellose sodium, magnesium stearate, microcrystalline cellulose.

The tablets are film-coated. The composition of the shell includes the following inactive components: red iron oxide, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide.